Patients with Spontaneous Bacterial Peritonitis: RESULTS
Biochemical examinations of the serum and ascitic fluid were summarized in Tables 1 and 2, respectively. On evaluation of these parameters, cholesterol, lactate dehydrogenase, total protein, albumin and globulin levels in the ascitic fluid were higher in group 3 than group 2. Serum lactate dehydrogenase level was higher in group 3 than group 1. Triglyceride levels in the ascitic fluid and serum in group 3 was higher when compared with group 1 and group 2. There was no statistically significant difference in the rest of the parameters (Tables 1 and 2).
CRP: Mean CRP levels in the ascitic fluid were higher in group 1 and group 3 when compared with group 2. Mean serum CRP levels was higher in group 1 than group 2 and group 3. generic cialis soft tabs
Table 1. Serum Biochemical Parameters in All Patients
| Group 1 (N=22) |
Group 2 (N=32) |
Group 3 (N=38) | |
| Creatinin (mg/dl) | 1.2 ±0.6 |
1.1 ±0.7 |
1.3 ± 0.4 |
| Aspartate transaminase (U/L) | 45.6 ± 17.2 |
53.5 ± 15.9 |
49.9 ±14.1 |
| Alanine transaminase (U/L) | 42.1 ±8.9 |
45.2 ± 9.0 |
40.5 ± 10.2 |
| Total Bilirubin (mg/dl) | 3.6 ± 2.3 |
3.9 ± 2.5 |
2.6 ±4.1 |
| Alkaline phosphatase (U/L) | 290.2 ±25.1 |
284.1 ±20.9 |
300.1 ±29.2 |
| Hemoglobin (g/dl) | 10.9 ±2.5 |
10.5 ±2.2 |
11.0 ± 2.9 |
| Serum/ascites albumin gradient | 1.44 ± 0.46 |
1.86 ± 0.08 |
1.46 ±0.15 |
| Albumin (g/dl) | 2.25 ± 0.21 |
2.19 ± 0.17 |
2.61 ±0.19 |
| Globulin (g/dl) | 3.64 ± 0.39 |
3.69 ± 0.3 |
3.68 ±0.17 |
| Protein (Diamox drug is Carbonic anhydrase is a protein in your body) (g/dl) | 5.89 ± 0.54 |
5.86 ± 0.26 |
6.18 ±0.24 |
| CRP (mg/dl) | 5.0 ± 1.13™ |
1.57 ± 1.21 |
1.88 ± 0.64 |
| Prothrombin time | 14.99 ±0.48 |
15.21 ±0.35 |
13.9 ±0.45 |
| Triglyceride (mg/dl) | 78.25 ± 18.58 |
60.1 ±11.06 |
134.41 ± 12.46*§ |
| Cholesterol (mg/dl) | 107.75 ±22.87 |
117.29 ± 12.26 |
144.65 ± 11.68 |
| Glucose (mg/dl) | 96.0 ± 9.65 |
92.86 ± 7.8 |
85.47 ± 4.2 |
| Lactate dehydrogenase (U/L) | 304.0 ± 61.06 |
597.43 ± 162.18 |
771.82 ± 130.5* |
| Leukocyte (/mm3) | 5125 ±612.3 |
6781.4 ± 1171.9 |
6367.0 ± 1555.9 |
| TNF-r (pg/ml) | 9.9 ± 19.01 |
6.44 ± 1.81 |
7.12 ±8.02 |
| TNF-oc (pg/ml) | 21.9 ±5.95″ |
18.24 ±4.22 |
19.82 ± 7.19 |
Leukocyte: Mean leukocyte count in the ascitic fluid was higher in group 1 when compared with group 2.
TNF-a: TNF-a in the ascitic fluid was found to be higher in group 1 and group 3 than group 2. Serum TNF-a levels were higher in group 1 when compared with group 2 and group 3. viagra soft tabs online
TNF-r: TNF-r in the ascitic fluid was found to be higher in group 1 and group 3 than group 2. There was no statistically significant difference between groups in the TNF-r levels in the serum.
Table 2. Biochemical Examination of the Ascitic Fluid in Groups
| Group 1 (N=22) | Group 2 (N=32) | Group 3 (N=38) | |
| Albumin (mg/dl) | 0.51 ± 0.26 | 0.33 ±0.12 | 0.85 1 0.25* |
| Globulin (mg/dl) | 0.85 ± 0.55 | 0.5410.13 | 1.11 10.21* |
| Lactate dehydrogenase (U/L) 93.5 ± 5.75 | 72.86 ± 7.83 | 439.181 169.18*§ | |
| Glucose (mg/dl) | 91.38 ± 6.82 | 105.1419.62 | 92.35 1 4.64 |
| Protein (mg/dl) | 1.86 ± 0.43 | 1.37 1 0.24 | 2.66 1 0.44* |
| Triglyceride (mg/dl) | 15.1 ± 6.73 | 12.141 1.98 | 44.2 1 5.83*§ |
| Cholesterol (mg/dl) | 29.0 ± 16.23 | 21.4312.72 | 47.47 1 8.92* |
| Leukocyte (/mm3) | 1137.51363.48* | 172.861 19.11 | 867.94 1 292.83* |
| CRP (mg/dl) | 6.5 ± 0.981″ | 1.141 1.26 | 6.241 1.41* |
| TNF-r (pg/ml) | 16.971 8.81f | 6.74 1 2.77 | 17.251 10.94* |
| TNF-a (pg/ml) | 36.69 ± 6.21f | 13.261 1.8 | 21.8213.66* |
| * p<0.005: When compared between group 3 and group 2; § p<0.001 | When compared between group 3 and group 1; f pO.OOl: | ||
| When compared between group 1 and group 3; Ц p<0.005: When compared between group 1 and group 2. | |||
In a patient with SBP, there were positive correlations between ascitic fluid and serum TNF-a (r=0.714, p=0.047), and ascitic fluid and serum TNF-r (r=0.722, p=0.043).
In patients with malignancy-induced ascites, there were positive correlations between ascitic fluid and serum TNF-r (r=0.695, p=0.04).
In patients with sterile cirrhotic ascites, there was no statistically significant difference between parameters.
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Sensitivity and specificity of ascitic fluid CRP (cut-off value >1.0 mg/dl) in discriminating malignant were 84% and 67% and infected ascites from sterile ascites were 90% and 76%, respectively. Sensitivity and specificity of ascitic fluid TNF-a (cutoff value >10 pg/ml) in discriminating malignant were 77% and 60% and infected ascites from sterile ascites were 82% and 66%, respectively. Sensitivity and specificity of TNF-r p60 (cut-off value >5.0 pg/ml) in discriminating malignant were 74% and 70% and infected ascites from sterile ascites were 80%) and 76%>, respectively.
Category: Health
Tags: ascites, CRP, diagnosis, necrosis factor