Acrokeratosis Paraneoplastica with Adenocarcinoma of the Colon Treated with Topical Tretinoin

Acrokeratosis paraneoplastica


Acrokeratosis paraneoplastica (Bazex syndrome) is a rare disorder characterized by the presence of hyperkeratotic lesions involving the nose, ears, palms, and soles that appears in association with various malignancies. It was first reported by Gougerot and Grupper in 1922. Cutaneous lesions manifest as violaceous to erythematous psoriasiform lesions favoring the acral areas and including the hands, feet, nose, ears, and nails, with subungal hyperkeratotic and onycholytic lesions. Most of the affected patients are white males, approximately 40 years of age. The most common associated neo­plasms are malignancies of the upper aerodigestive system, and other kinds of tumors with cervical lymph node metastasis, but there are some cases that develop from other tumors in the prostate, bladder, thymus, leg, and breast. A case of Bazex syndrome associated with adenocarcinoma of the colon was first reported in 2000. No other cases of Bazex syndrome associated with colon cancer have been published in the English literature to date.

We report a case of acrokeratosis paraneoplastica associated with colon cancer which persisted after removal of the primary tumor, but improved with topical tretinoin treatment. kamagra soft tabs