Toxic Epidermal Necrolysis Induced
INTRODUCTION
Carbonic anhydrase inhibitors (CAI) are commonly used for lowering the intraocular pressure (IOP) in glaucoma and other ophthalmologic conditions. Carbonic anhydrase inhibitors are sulfonamide derivatives that are known to cause a range of adverse reactions, including benign transient cutaneous rashes to life-threatening conditions, such as Toxic epidermal necrolysis (TEN). Systemic CAIs are among the most potent medications for lowering IOP, but their use is accompanied by troublesome side effects. In the dermatologic literature, there are reports of Stevens-Johnson syndrome (SJS) and TEN associated with systemic CAIs in people of Japanese or Korean descent.
Topical application of intraopthalmic CAIs is now recommended to control intraocular pressure, as since the introduction of topical CAI in 1995 there have been significantly lower incidences of various side effects. However, SJS-TEN associated with topical CAI has been recently reported. Here, we report 2 cases of TEN that were induced by topical CAIs, brinzolamide and dorzolamide, in 2 Korean men.
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