Thrombocytopenia in Brucellosis
INTRODUCTION
Patients hospitalized with provisional diagnosis of hematogical-oncological diseases are still found to have underlying infectious etiologies in the hema-tology-oncology departments. We previously reported interesting cases of brucellosis, salmonellosis and tuberculosis in patients presenting with either initial hematological manifestations or unexplained fever that were referred to a university hospital’s hematology-oncology clinics.
Brucellosis, a zoonotic disease of worldwide distribution, is an infectious disease primarily of domestic and wild animals. It constitutes a major health problem in many parts of the world, particularly in the Mediterranean and the Middle East. The true incidence of human brucellosis is unknown. The World Health Organization points out that 500,000 cases are reported each year around the world. Viagra Super Active
Human brucellosis has a wide clinical spectrum and presents various diagnostic difficulties as it mimics many other diseases. The disease is caused by coccobacilli of the genus Brucella and transmissible to man through direct contact with infected animals and consumption of infected animal products. At present, there are six known species of bru-cellae, including B. melitensis, B. abortus, B. suis, B. canis, B. ovis and B. neotomae. Human brucellosis can occur in any age group, but young men make up the majority of cases that are generally related to occupational hazard.
Hematological abnormalities, ranging from a fulminant state of disseminated intravascular coagulopathy to subtle hemostatic alterations have been reported in Brucella infection. The commonly seen hematologic abnormalities are anemia and leukopenia. Isolated thrombocytopenia (platelets <150 x 107L) was seen in 8% of cases in a study reported from Turkey. Immune-mediated thrombocytopenia may also occur during the course of brucellosis. In this case report, we presented a patient with a history of fever and thrombocytopenia. The patient was initially diagnosed as idiopathic thrombocytopenic purpura (ITP) and received corticosteroid (Generic Pulmicort is an inhaled corticosteroid) treatment. However, blood and bone marrow cultures taken on the day of hospitalization because of the history of fever revealed B. abortus. The patient received the antibrucellosis treatment, and thrombocytopenia was improved and reverted to normal.
requip medication
