CDllb and CD 18 are members of the integrin family of adhesion molecules, which consist of transmembrane glycoproteins expressed primarily on neutrophils and monocytes. They form heterodimer complexes from the noncovalent union of the alpha and beta subunits before being transported to the cell sur face. In this regard, the CD 18 (beta2) integrin combines [...]
CDl lb and CD 18 expressions on neutrophils and monocytes from arterial and venous samples were measured before, during and after aortic clamping. After reperfusion, CDl lb expression on venous and arterial neutrophils rose significantly, reaching a peak at 34.4 ± 27 minutes on venous neutrophils and 38.5 ±16 minutes on arterial neutrophils (Figure 1, [...]
Institutional human subjects committee approval and individual informed consent were obtained prior to the study. Eight Caucasian male patients aged 55-81 with past history of hypertension, tobacco smoking and arteriosclerotic cardiovascular disease undergoing elective infrarenal abdominal aortic aneurysm repair were studied. Radial artery and pul- induction of general anesthesia, a right femoral vein monary artery [...]
Ischemia and reperfusion result in leukocyte activation, adhesion and infiltration, which can extend tissue injury in experimental stroke and myocardial infarction. Activated neutrophils are considered the primary mediators of tissue destruction following ischemia and reperfusion. This involves adhesion to the endothelial surface and tissue infiltration, followed by eventual release of toxic reactive oxygen metabolites and [...]
