Medical Inspection – Health Blog

Acrokeratosis paraneoplastica is an example of a paraneoplastic syndrome which reflects an underlying malignancy. The clinical manifestations include palmoplantar keratoderma, violaceous psoriasiform papulosquamous lesions, hyperpigmentation, and nail dystrophy. Acrokeratosis paraneoplastica has a characteristic symmetric bilateral acral distribution, primarily affecting white males of French extraction over 40 years of age. The most common associated neoplasms are [...]

A 63-year-old Korean woman visited our der- matologic clinic with an 11 month history of hyperkeratotic lesions on the palms and soles. The routine laboratory tests, including a complete blood count, liver function tests, and urine analysis revealed values all within the normal range or negative findings. The physical examination revealed yellowish punctuate hyperkeratotic lesions [...]

INTRODUCTION Acrokeratosis paraneoplastica (Bazex syndrome) is a rare disorder characterized by the presence of hyperkeratotic lesions involving the nose, ears, palms, and soles that appears in association with various malignancies. It was first reported by Gougerot and Grupper in 1922. Cutaneous lesions manifest as violaceous to erythematous psoriasiform lesions favoring the acral areas and including [...]

Speaker: Vincent Rajkumar, MD, Hematologist, Mayo Clinic, Rochester, Minnesota. Patients with newly diagnosed multiple myeloma responded better to treatment with the oral drug combination of thalidomide (Thalomid®, Celgene) plus dexamethasone (Decadron generic, Merck) (thal/dex) than to dexamethasone therapy alone.

Speaker: Joseph J. McKendrick, MD, Director of Medical Oncology, Department of Clinical Hematology and Clinical Oncology, Box Hill Hospital, Melbourne, Victoria, Australia. Adjuvant chemotherapy with oral capecitabine (Xeloda®, Roche), an oral fluoropyrimidine preferentially activated to 5-fluorouracil (5-FU) in tumors by enzymatic action, was more cost-effective than the standard Mayo Clinic regimen of IV 5-FU and [...]

Speaker: Roger Stupp, MD, Professor of Medicine and Director, Brain Tumor and Chest Oncology Clinic, Multi-disciplinary Oncology Center, University of Lausanne Hospital, Vaudois, Lausanne, Switzerland. The addition of temozolomide (Temodar®, Schering), a chemotherapeutic agent indicated for the treatment of ana-plastic astrocytoma, to standard radiation therapy significantly improved both progression-free survival and overall survival in patients [...]

Nanoparticle Albumin-Bound Paclitaxel for Metastatic Breast Cancer Speaker: William J. Gradishar, MD, Associate Professor of Medicine; Director, Breast Oncology; and Director, Fellowship Program, Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.