INTRODUCTION The ill elderly often present with elevated nutritional risk and a history of weight loss. Elderly patients who lose weight during hospital admissions have an eight-fold greater in-hospital and nearly three-fold greater 90-day mortality, when compared to patients without significant weight loss.
Out of 120 eligible patients receiving doxorubicin combination therapy at Howard during the study period, 100 patients were evaluable, all of whom were African American (65% women, 35% men, median age 46 years, range 32-84 years). Fifteen patients had hypertension, and 10 were diabetics. None of the patients had history of CHF or coronary artery [...]
A retrospective survey of the Howard University Hospital cancer registry during 1997-2001 was conducted to identify all patients who underwent Adriamycin-based combination chemotherapy. Charts were reviewed to find evaluable patients who had records of the cumulative dose of doxorubicin and assessment of clinical cardiac status and echocardiogram both before therapy and at one- to four [...]
INTRODUCTION In 1957 streptomyces peucetius was isolated from southern Italian soil. The compound 1, 4-hydroxydaunomycin was produced by a variant strain and called Adriamycin (Adria) because of the proximity of the parent strain source to Adriatic Sea. Doxorubicin hydrochloride, the generic name for Adriamycin, has a leading role in the treatment of hematological malignancies and [...]
Search for candidate polymorphisms should focus on those affecting the pathways described above that differ in frequency between the white and black populations. Definitive evidence that genetic factors contribute to racial disparity in PTD requires identification of polymorphisms that: 1) differ in frequency by race among representative populations, 2) are independently associated with PTD for [...]
Genetic expression (phenotype) occurs within а specific environmental context. In this sense, pheno-types represent interaction between genes and environment. However, the term “gene-environment interaction” typically is used in a narrower sense to refer to effect modification whereby the size or even the direction of the genetic effect differs depending on environmental risk.
Population-level differences in outcomes can be attributable to differences in environmental exposures, differences in gene frequency or, more frequently, interaction between multiple genes and environment. Recurrent PTD contributes significantly to racial disparity in PTD, but risk of recurrence may simply represent continued exposure to environmental risk factors or biological predisposition as a result of an [...]
