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Patients with Spontaneous Bacterial Peritonitis: RESULTS

Biochemical examinations of the serum and ascitic fluid were summarized in Tables 1 and 2, respectively. On evaluation of these parameters, cholesterol, lactate dehydrogenase, total protein, albumin and globulin levels in the ascitic fluid were higher in group 3 than group 2. Serum lactate dehydrogenase level was higher in group 3 than group 1. Triglyceride levels in the ascitic fluid and serum in group 3 was higher when compared with group 1 and group 2. There was no statistically significant difference in the rest of the parameters (Tables 1 and 2).

CRP: Mean CRP levels in the ascitic fluid were higher in group 1 and group 3 when compared with group 2. Mean serum CRP levels was higher in group 1 than group 2 and group 3. generic cialis soft tabs

Table 1. Serum Biochemical Parameters in All Patients

Group 1 (N=22)

Group 2 (N=32)

Group 3 (N=38)
Creatinin (mg/dl) 1.2 ±0.6

1.1 ±0.7

1.3 ± 0.4
Aspartate transaminase (U/L) 45.6 ± 17.2

53.5 ± 15.9

49.9 ±14.1
Alanine transaminase (U/L) 42.1 ±8.9

45.2 ± 9.0

40.5 ± 10.2
Total Bilirubin (mg/dl) 3.6 ± 2.3

3.9 ± 2.5

2.6 ±4.1
Alkaline phosphatase (U/L) 290.2 ±25.1

284.1 ±20.9

300.1 ±29.2
Hemoglobin (g/dl) 10.9 ±2.5

10.5 ±2.2

11.0 ± 2.9
Serum/ascites albumin gradient 1.44 ± 0.46

1.86 ± 0.08

1.46 ±0.15
Albumin (g/dl) 2.25 ± 0.21

2.19 ± 0.17

2.61 ±0.19
Globulin (g/dl) 3.64 ± 0.39

3.69 ± 0.3

3.68 ±0.17
Protein (Diamox drug is Carbonic anhydrase is a protein in your body) (g/dl) 5.89 ± 0.54

5.86 ± 0.26

6.18 ±0.24
CRP (mg/dl) 5.0 ± 1.13™

1.57 ± 1.21

1.88 ± 0.64
Prothrombin time 14.99 ±0.48

15.21 ±0.35

13.9 ±0.45
Triglyceride (mg/dl) 78.25 ± 18.58

60.1 ±11.06

134.41 ± 12.46*§
Cholesterol (mg/dl) 107.75 ±22.87

117.29 ± 12.26

144.65 ± 11.68
Glucose (mg/dl) 96.0 ± 9.65

92.86 ± 7.8

85.47 ± 4.2
Lactate dehydrogenase (U/L) 304.0 ± 61.06

597.43 ± 162.18

771.82 ± 130.5*
Leukocyte (/mm3) 5125 ±612.3

6781.4 ± 1171.9

6367.0 ± 1555.9
TNF-r (pg/ml) 9.9 ± 19.01

6.44 ± 1.81

7.12 ±8.02
TNF-oc (pg/ml) 21.9 ±5.95″

18.24 ±4.22

19.82 ± 7.19

Leukocyte: Mean leukocyte count in the ascitic fluid was higher in group 1 when compared with group 2.
TNF-a: TNF-a in the ascitic fluid was found to be higher in group 1 and group 3 than group 2. Serum TNF-a levels were higher in group 1 when compared with group 2 and group 3. viagra soft tabs online

TNF-r: TNF-r in the ascitic fluid was found to be higher in group 1 and group 3 than group 2. There was no statistically significant difference between groups in the TNF-r levels in the serum.

Table 2. Biochemical Examination of the Ascitic Fluid in Groups

Group 1 (N=22) Group 2 (N=32) Group 3 (N=38)
Albumin (mg/dl) 0.51 ± 0.26 0.33 ±0.12 0.85 1 0.25*
Globulin (mg/dl) 0.85 ± 0.55 0.5410.13 1.11 10.21*
Lactate dehydrogenase (U/L)        93.5 ± 5.75 72.86 ± 7.83 439.181 169.18*§
Glucose (mg/dl) 91.38 ± 6.82 105.1419.62 92.35 1 4.64
Protein (mg/dl) 1.86 ± 0.43 1.37 1 0.24 2.66 1 0.44*
Triglyceride (mg/dl) 15.1 ± 6.73 12.141 1.98 44.2 1 5.83*§
Cholesterol (mg/dl) 29.0 ± 16.23 21.4312.72 47.47 1 8.92*
Leukocyte (/mm3) 1137.51363.48* 172.861 19.11 867.94 1 292.83*
CRP (mg/dl) 6.5 ± 0.981″ 1.141 1.26 6.241 1.41*
TNF-r (pg/ml) 16.971 8.81f 6.74 1 2.77 17.251 10.94*
TNF-a (pg/ml) 36.69 ± 6.21f 13.261 1.8 21.8213.66*
* p<0.005: When compared between group 3 and group 2; § p<0.001 When compared between group 3 and group 1; f pO.OOl:
When compared between group 1 and group 3; Ц p<0.005: When compared between group 1 and group 2.

In a patient with SBP, there were positive correlations between ascitic fluid and serum TNF-a (r=0.714, p=0.047), and ascitic fluid and serum TNF-r (r=0.722, p=0.043).

In patients with malignancy-induced ascites, there were positive correlations between ascitic fluid and serum TNF-r (r=0.695, p=0.04).

In patients with sterile cirrhotic ascites, there was no statistically significant difference between parameters.
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Sensitivity and specificity of ascitic fluid CRP (cut-off value >1.0 mg/dl) in discriminating malignant were 84% and 67% and infected ascites from sterile ascites were 90% and 76%, respectively. Sensitivity and specificity of ascitic fluid TNF-a (cutoff value >10 pg/ml) in discriminating malignant were 77% and 60% and infected ascites from sterile ascites were 82% and 66%, respectively. Sensitivity and specificity of TNF-r p60 (cut-off value >5.0 pg/ml) in discriminating malignant were 74% and 70% and infected ascites from sterile ascites were 80%) and 76%>, respectively.

Tags: ascites, CRP, diagnosis, necrosis factor