Whether omeprazole was given once or twice daily in combination with clarithromycin and metronidazole, this one- week treatment regimen achieved 80% ITT, 85% APT and 86% to 87% PP Hpylori eradication. Due to small sample size, statistically significant differences may have been missed. However, because the results were exactly the same in both study arms, [...]
A total of 103 patients were initially enrolled in the study. Of these, 51 were in the omeprazole once daily arm and 52 were allocated to the omeprazole twice daily arm. Three patients were lost to follow-up immediately after the first visit and were excluded because it was not known whether any medications had been [...]
Patients were recruited from a single gastroenterology practice in Guelph, Ontario. Guelph has 94,000 inhabitants and is located near several large academic medical centres. In this community, it is not possible to culture H pylori and perform antibiotic susceptibility testing. The nearest centre performing C urea breath tests is a large teaching centre in Hamilton, [...]
In 1993, Bazzoli introduced the highly effective Helicobacter pylori eradication regimen of omeprazole 20 mg once daily, clarithromycin 250 mg bid and tinidazole 500 mg bid for one week. However, tinidazole is not available in Canada. Since that time, many other studies using a proton pump inhibitor (PPI) in combination with clarithromycin and another nitroimidazole, [...]
