Medical Inspection – Health Blog

Patients were referred for the management of hypercarbia from the Muscular Dystrophy Association Clinic at New England Medical Center. Patients had been diagnosed as having Duchenne or Duchenne-type muscular dystrophy using standard clinical criteria including male sex, elevation of creatine phosphokinase, and a compatible muscle biopsy and clinical picture. All patients were in functional class [...]

Duchenne and Duchenne-type muscular dystrophies are x-linked recessive hereditary disorders characterized by diffuse skeletal and cardiac muscle involvement. They lead inexorably to quadraparesis in the preteen years and death due to respiratory failure at an average age of 20 years or slightly older for the more slowly progressive Duchenne-type dys­trophies. Although the use of ventilatory [...]

Brinzolamide and dorzolamide are highly specific topical CAIs, which lower intraocular pressure (IOP) by reducing the rate of aqueous humour formation. Although systemic CAIs are the most potent medications for lowering intraocular pressure for primary open-angle glaucoma and other con­ditions with ocular hypertension, many cases with adverse systemic reactions have been reported, including Stevens-Johnson syndrome [...]

Case 1 A 45-year-old Korean man, who had alcoholic liver cirrhosis, suddenly developed blurred vision accompanied by a headache. After emergency ophthalmic surgery, topical brinzolamide was ap­plied to his eyes to control post-operative intra­ocular pressure resulting from pre-existing glau­coma. Two weeks later, after applying brinzolamide 3 times a day, the patient reported pruritic erythematous to [...]

INTRODUCTION Carbonic anhydrase inhibitors (CAI) are com­monly used for lowering the intraocular pressure (IOP) in glaucoma and other ophthalmologic conditions. Carbonic anhydrase inhibitors are sulfo­namide derivatives that are known to cause a range of adverse reactions, including benign transient cutaneous rashes to life-threatening conditions, such as Toxic epidermal necrolysis (TEN). Systemic CAIs are among the [...]

However, continual overexpression of VEGF has been found to result in hemangioma-type tumors , indicating that the VEGF expression or effective dose must be tightly regulated and that the ex­pression must transiently occur only at the early stage of wound healing. Furthermore, the micro- vessels that develop from the continual over- expression of VEGF were [...]

The angiogenic effect of Ang 1 has been reported in previous studies. Ang 1 and Tie 2-deficient mice had similar phenotypes that were characterized by embryonic lethality with severe vascular remodeling defects, insufficient vessel stabilization and perturbed vascular maturation. Promoted angio- genesis has been reported on for transgenic mice that overexpress Ang 1 in the [...]