Atrial Fibrillation in a Multiethnic Inpatient Population of a Large Public Hospital: RESULTS
Table 1 presents the characteristics of the cohort. Age, gender, and race status were available in 99.9% of the cohort. The four preselected racial groups (Caucasian, Hispanic, African-American, and Asian) comprised 97% of the cohort. Nearly 60% of the subjects were Hispanic. The mean age (SD) of the cohort was 62.3 (15.1) years. Nearly 28% of the cohort were younger than 55 years; 29.6%, 55-64 years; 19.9%, 65-74 years; 15.1% 75-84 years. The African-American group had the youngest mean age. The difference in mean age was significant between African-American and Caucasian subjects. Neither Hispanic nor Asian subjects were different from Caucasian subjects in mean age. Forty-four percent of the overall cohort were women; in the Hispanic group, women had a slight majority (51% vs. 49%). The Caucasian group had the most uneven distribution of gender. Medicaid and Medicare accounted for 65.9% of the cohort’s medical liability, while private insurance accounted for 3.5% of the cohort and 30.6% were uninsured.
Figure 1 presents the percentage of each sex stratified by age. Men outnumbered women in the younger age groups (except 35-44), while women outnumbered men in the older age groups. Similar distribution was seen for each race (not shown). Figure 2 presents the percentage of each race stratified by age. The distribution of each racial group approximates a normal distribution, peaking at 55-64 years. The African-American group also has an early peak at 35-44 years. canadian antibiotics
Figure 1. Age Distribution of Atrial Fibrillation Stratified by Sex Ages for female and male patients are plotted by decile for the study population. Males predominate only in the 45-54 and 55-64 deciles, while females predominate in the 35-44 and over-65 age groups.
Table 2 presents the electrocardiographic findings (parameters and diagnoses) in the cohort and among the racial groups. Approximately one-fifth of the cohort had concomitant finding of myocardial infarction, evenly distributed among the racial groups. Right bundle branch block occurred more often than left bundle branch block. The prevalence of complete heart block in the cohort was small (not shown). Nonspecific ST- and/or T-wave changes were prevalent in 28.3% of subjects, evenly distributed among the racial groups. Nearly half of the subjects had tachycardia. The only statistically significant difference between groups was in LVH; African-American and Asian subjects were 2.3 and 2.6 times more likely to have LVH than Caucasian subjects, respectively. cheap antibiotics
Figure 2. Age Distribution of Atrial Fibrillation Stratified by Race Although Hispanics made up over 50% of this total group, they did not predominate in any single decile except the <35, in contrast to Caucasians (55-64, >85), African Americans (35-44, 65-74), and Asians (75-84).
Table 3 presents the discharge medical diagnoses among the racial groups. Hypertension was present in nearly half of the subjects. Diagnosed heart failure accounted for one-third of the subjects. A small number of subjects had cerebral vascular and embolic events. Pairwise comparisons show that Caucasian subjects were statistically more likely to have coronary artery disease than Hispanics, African Americans, and Asians but were less likely to have rheumatic heart disease than Hispanics and to have cardiomyopathy than African Americans. The occurrence of diabetes was equal among Hispanic, Asian, and Caucasian subjects and lower in African-American subjects as compared to Caucasian subjects (nonsignificant). viagra soft
Table 1. Baseline Characteristics of 737 Inpatient Subjects with Diagnosed Atrial Fibrillation
| Cohort | Caucasian | Hispanic | African-American | Asian | Other | |
| Number of patients (%) |
737 |
121 (16.4) |
436 (59.2) |
76 (10.3) |
82 (11.1) |
22 (2.9) |
| Age (mean, year) |
62.3 |
64.2 |
61.8 |
59.4f |
64.2 |
63.9 |
| Gender | ||||||
| Male, % |
56 |
77 |
49 |
58 |
57 |
64 |
| Female, % |
44 |
23 |
51 |
42 |
43 |
36 |
| Types of Insurance | ||||||
| Medi-Cal |
49.9 |
31.4 |
57.3 |
42.1 |
40.2 |
35.5 |
| Medicare |
16 |
19 |
11.9 |
27.6 |
24.4 |
15.7 |
| Private/HMO |
3.5 |
9.1 |
2.3 |
2.6 |
2.6 |
4.2 |
| Uninsured |
30.6 |
4.05 |
28.5 |
27.7 |
32.8 |
44.6 |
| * Variables are expressed as percent (categorical data) and means (continuous data); t Significantly different from Caucasian subjects (PO.05). | ||||||
Table 2. Electrocardiographic Findings
|
Variables |
Overall (%) |
Caucasian (%) |
Hispanic (%), Odds Ratio (95% CI) |
African-American (%), Odds Ratio (95% CI) |
Asian (%), Odds Ratio (95% CI) | ||
| Ml |
22.1 |
20.7 |
21.6 | 1.06 (0.65-1.7) |
22.4 |
1.07 (0.53-2.2) |
23.2 1.16(0.59-2.3) |
| LVH |
15.2 |
9.9 |
13.5 | 1.49 (0.77-2.9) |
21.1 |
2.3f (1.02-5.3) |
15.3 2.76f (1.25-6.1) |
| RBBB |
15.2 |
12.4 |
17 | 1.45 (0.80-2.6) |
11.8 |
1.06 (0.43-2.6) |
13.3 1.2 (0.54-2.7) |
| LBBB | 6.5 |
5.8 |
6.7 | 1.23 (0.52-2.9) |
10.5 |
1.96 (0.67-5.7) |
4.4 0.41 (0.08-2) |
| Tachycardia |
49.7 |
49.6 |
49.5 | 0.99 (0.65-1.5) |
53.9 |
1.11 (0.61-2.0) |
42.7 0.8 (0.42-1.3) |
| ST- or T-wave | |||||||
| abnormalities |
52.8 |
49.6 |
53 | 1.15 (0.77-1.7) |
47.4 |
0.84 (0.47-1.5) |
58.5 1.44 (0.82-2.5) |
| Prolonged QTC |
28.3 |
24.8 |
27.9 | 1.22 (0.77-1.9) |
28.9 |
1.37 (0.71-2.7) |
30.5 1.3 (0.71-2.5) |
| * Variables are expressed as percent odds ratios are age-adjusted from logistic regression, representing pairwise comparisons between Hispanic, African-American, or Asian subjects with Caucasian subjects. CI: confidence intervals; Ml: myocardial infarction; LVH: left ventricular hypertrophy; LBBB: left bundle branch block; RBBB: right bundle branch block; and ST segment, QT segments, and T-waves are conventional electrocardiographic nomenclatures; t P<0.05 | |||||||
Among 737 total subjects, 603 were discharged alive home or to an alternate facility, 103 expired during the hospitalization, and one patient remained hospitalized at the end of the observation period. The inpatient mortality rate was 16%. The mean age of the discharged alive vs. deceased patients was 65 compared to 62 (P<0.05). The racial distribution of alive vs. deceased, shown in Table 4, was not different. Myocardial infarction, CVA, and valvular heart disease were significantly more common in the non-survivor group, as might be expected.
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Table 3. Medical Diagnoses
|
Variables |
Overall (%) |
Caucasian (%) |
Hispanic (%), Odds Ratio (95% CI) |
African-American (%), Odds Ratio (95% CI) |
Asian (%), Odds Ratio (95% CI) |
|||
| Hypertension |
45.6 |
43 |
44.7 |
1.2 (0.8-1.8) |
52.6 |
1.75 (0.96-3.2) |
46.3 |
1.15 (0.64-2.0) |
| Heart failure |
31.1 |
28.1 |
30.3 |
1.15 (0.7-1.8) |
39.5 |
1.8 (0.99-3.4) |
28 |
1.0 (0.53-1.9) |
| Diabetes |
22.9 |
22.3 | 25 |
1.2 (0.7-1.9) |
17.1 |
0.77 (0.37-1.6) |
20.7 |
0.91 (0.46-1.8) |
| CAD |
18.5 |
26.4 |
17.7 |
0.621 (0.4-0.99) |
10.5 |
0.36f (0.15-0.83) |
8.5 |
0.25* (0.11-0.61) |
| Acute Ml | 00 | 8.3 |
8.5 |
1.03 (0.5-2.1) |
5.3 |
0.66 (0.2-2.2) |
8.5 |
1.03 (0.38-2.8) |
| All valve diseases |
13.4 |
11.6 | 14 |
1.16 (0.62-2.2) |
14.5 |
1.2 (0.52-2.9) |
12.2 |
1.1 (0.44-2.5) |
| Mitral valve disease |
10.4 |
7.4 |
11.9 |
1.6 (0.7^-3.3) |
6.6 |
0.82 (0.26-2.6) |
9.8 |
1.3 (0.49-3.7) |
| Chronic rheumatic heart disease |
5.8 |
1.7 |
7.8 |
4.6* (1.1-19.6) |
3.9 |
1.9 (0.3-12.5) |
3.7 |
2.2 (0.36-13.7) |
| Cardiomyopathy |
4.5 |
2.5 |
3.9 |
1.5 (0.4^5.4) |
10.5 |
4.21 (1.06-16.7) |
4.9 |
1.96 (0.42-9.2) |
| CVA |
6.6 |
5 |
6.9 |
1.49 (0.6^-3.7) |
7.9 |
1.76 (0.54-5.8) |
8.5 |
1.8 (0.58-5.7) |
| Cerebral embolism |
1.8 |
0.8 |
1.6 |
2.1 (0.25-17) |
2.6 |
3.2 (0.28-36.6) |
3.7 |
4.7 (0.47-46.5) |
| * Variables are expressed as percent odds ratios are age-adjusted from logistic regression, representing pairwise comparisons among Hispanic, African-American, or Asian subjects with Caucasian subjects. CI: confidence intervals; HF: heart failure; Ml: myocardial infarction; CAD: coronary artery disease; and CVA: cerebral vascular accidents; t P<0.05; t P<0.01 | ||||||||
Table 4. Comparison of Clinical Variables among Survivors vs. Nonsurvivors
|
Variable |
Expired |
Alive |
P-Value |
| Age (mean) |
64.98 |
61.85 |
0.05 |
| Gender | |||
| Male |
61 (59.2%) |
352 | |
| Female |
42 (40.8%) |
282 | |
| Race | |||
| Caucasian |
17 (16.5%) |
104 (16.4%) | |
| African-American |
12 (11.7%) |
64 (10.1%) | |
| Hispanic |
53 (51.5%) |
383 (60.4%) | |
| Asian |
17 (16.5%) |
65 (10.3%) | |
| Other |
4 (3.9%) |
18 (2.8%) | |
| Admission Type | |||
| Emergency |
89 (86.4%) |
523 (82.5%) | |
| Urgent |
3 (2.39%) |
16 (2.5%) | |
| Elective |
11 (10.7%) |
95 (15%) | |
| Discharge Dx | |||
| HTN |
41 (39.8%) |
295 (46.5%) | |
| CHF |
32 (31.1%) |
197 (31.1%) | |
| CMP |
7 (6.8%) |
26 (4.1%) | |
| Diabetes |
26 (25.2%) |
143 (22.6%) | |
| Ml |
21 (20.4%) |
39 (6.2%) |
0.000 |
| Valvular disease |
8 (7.8%) |
91 (14.4%) |
0.085 two-sided, 0.042 one-sided |
| Mitral valve |
5 (4.9%) |
72 (11.4%) |
0.054 two-sided. |
|
0.027 one-sided |
|||
| Hyperthyroid |
1 (1.0%) |
29 (4.6%) | |
|
3 (2.9%) |
10 (1.6%) | ||
| Pulmonary embolism |
5 (4.9%) |
7 (1.1%) |
0.017 |
| Peripheral embolism |
1 (1.0%) |
2 (0.3%) | |
| Acute EtOH |
0 |
10 (1.6%) | |
| Carditis |
3 (2.9%) |
11 (1.7%) | |
| Rheumatic |
3 (2.9%) |
40 (6.3%) | |
| Burn (third-degree) |
4 (3.9%) |
4 (0.6%) |
0.016 |
| Septicemia |
4 (3.9%) |
4 (0.6%) |
0.016 |
| CAD |
16 (15.5%) |
120 (18.9%) | |
| Arrhythmias |
15 (14.6%) |
60 (9.5%) | |
| CVA |
17 (16.5%) |
32 (5%) |
0.000 |
| Comparison between expired and alive groups showed statistical significance (Chi-squared test) for discharge diagnoses: Ml, pulmonary embolism, cerebral vascular accidents, septicemia, and burn (third-degree) | |||










