A Case of Angiolymphoid Hyperplasia with Eosinophilia of the Lower Eyelid: DISCUSSION
ALHE is characterized by persistent, recurrent dermal or subcutaneous nodules primarily in the hand and neck area. Although there is a predilection for the periauricular area, involvement of other skin surfaces as well as the oral mucous membranes, pharynx, and orbital has been reported. The lesions, which are often pruritic or painful, may coalesce into confluent plaques that are chronic with little propensity for spontaneous resolution. In some cases, peripheral blood eosinophilia is present.
The etiology of ALHE remains unknown. But there are several cases of ALHE in the literature that have been associated with pregnancy, and thus, sex hormones. High prevalence of the disease among women and occurrence of the disease associated with sex hormones are two important observations that sex hormones may play role in the pathogenesis of ALHE. Clinical presentation is very spread out, and the main differential diagnosis lies in the vascular tumors. The most important clinicopatho- logical differential diagnosis of ALHE is Kimura’s disease. These two conditions are very similar in that they occur in the head and neck region, particularly the periauricular area. Kimura’s disease mainly occurs in young Oriental males presenting with single or multiple large asymptomatic masses involving the subcutaneous tissue or salivary glands. It is often accompanied by regional lymph node enlargement, peripheral blood eosinophilia, an elevated serum IgE level, and nephrotic syndrome. By contrast, ALHE occurs in young to middle-aged females of any race, presenting with multiple small pruritic erythematous dermal papules or nodules without lymphadenopathy or laboratory abnormalities.
Histopathologically, in Kimura’s disease, multiple lymphoid follicles with germinal centers and massive eosinophilic infiltration with eosinophilic abscesses are very characteristic, but vascular proliferation is minimal. By contrast, in ALHE, diffuse lymphoid and eosinophilic infiltrations without lymphoid follicles or eosinophilic abscesses are observed. Endo- thelial proliferation is very prominent. The thick- walled blood vessels are lined with hypertrophic “epithelioid” or “histiocytoid” endothelial cells which protrude into the vascular lumen, occasionally resulting in a “cobblestone” appearance. There is no consistently effective treatment for this disease. Intralesional injections of glucocorticoid, interferon alpha-2a, and cytotoxic agents may be effective. Although surgical excision can be curative, recurrences are common. Destructive techniques such as cryotherapy and electrodesiccation may be attempted. In addition, pulse-dye lasers have been used to selectively target the vasculoproliferative component of dis orders. tadacip 20 mg
The most common location of ALHE is head and neck, especially on the scalp, although it can be seen other areas (trunk, extremities, groin). To date, 8 cases of ALHE have been reported in the Korean literature, but only 1 case has reported ALHE occurring on the face. Our patient had a single asymptomatic papule on the lower eyelid. The skin biopsy showed vascular proliferation, with prominent endothelial cells with lymphocyte and eosinophil infiltration, which suggested ALHE. The entire lesion was excised.
In conclusion, ALHE may be seen as one of the differential diagnoses of a lesion involving a single erythematous papule on the lower eyelid in a young adult.
