Treatment and complications: Medications included 5- aminosalicylates, steroids and immunosuppressants as well as antimicrobial agents. In most patients, more than one medication was administered during the course of their treatment, particularly for Crohn’s disease. For both groups, most were treated with corticosteroids and/or immunosuppressants during a mean follow-up period of five to six years. Some [...]
Patient population: In this prospectively studied population cohort of Indo-Canadians residing in the metropolitan area of Vancouver, a clinical diagnosis of ulcerative colitis was established in 62 of 84 patients (almost 75%) with IBD; the other 22 patients had Crohn’s disease (Table 1). This distribution contrasts with the results of a prospectively studied population of [...]
Laboratory studies: For each patient, all blood samples were collected into vacutainer glass tubes (Becton Dickinson, Franklin, New Jersey) by a laboratory technologist without knowledge of the patient’s clinical history, investigation results or diagnosis. Blood was also obtained for hematological studies (hemoglobin, white blood cell count and platelet count), erythrocyte sedimentation rate, antinuclear antibodies, liver [...]
Patient groups: Each patient had an established diagnosis of idiopathic ulcerative colitis or Crohn’s disease in the small and/or large intestine based on clinical, radiological, endo- scopic and histological criteria, and negative microbiological studies. Ulcerative colitis was diagnosed when a diffuse inflammatory process involving the rectum and extending proximally within the colon was present. As [...]
Previous studies have demonstrated that some antineutrophil cytoplasmic autoantibodies (ANCA) may be detected in patients with inflammatory bowel disorders, particularly in those with ulcerative colitis. Recently, in a prospective study of 500 Canadian patients with inflammatory bowel disease (IBD) who were evaluated at the University of British Columbia, 38.8% were positive for ANCA – 66.3% [...]
Whether omeprazole was given once or twice daily in combination with clarithromycin and metronidazole, this one- week treatment regimen achieved 80% ITT, 85% APT and 86% to 87% PP Hpylori eradication. Due to small sample size, statistically significant differences may have been missed. However, because the results were exactly the same in both study arms, [...]
A total of 103 patients were initially enrolled in the study. Of these, 51 were in the omeprazole once daily arm and 52 were allocated to the omeprazole twice daily arm. Three patients were lost to follow-up immediately after the first visit and were excluded because it was not known whether any medications had been [...]
