In the great majority of patients with Paget’s disease the diagnosis is made by X-ray evaluation of the affected region(s) of the skeleton. Although the lesions may be complex, comprised of osteolytic, osteosclerotic and/or mixed abnormalities, experienced evaluators of bone usually have little difficulty in distinguishing the characteristics of Paget’s disease from other disorders. Occasionally [...]
Deformity A hallmark of Paget’s disease is the presence of one or more skeletal deformities. The most readily apparent, but sometimes subtle, is enlargement of the skull (Figure 1). This usually produces somewhat asymmetric enlargement of the cranium. In individuals who wear hats a history of a slow increase in hat size may be volunteered [...]
Introduction Paget’s disease of bone is a skeletal disorder usually diagnosed in patients over the age of 50 years whose clinical presentation is highly variable. It may be suspected based on physical examination alone but more commonly is brought to attention by unexpected radiological or biochemical findings when an individual is under evaluation for another [...]
