Collecting Laboratory Data The collection of laboratory data usually precedes dosage calculations and computer order entry, as laboratory values may dictate pertinent dosage changes or delays in therapy, according to treatment protocols. The SPOT was trained via a didactic lecture (given by the pharmacy manager/clinical practice leader, A.L.) based on the content of the pharmacy [...]
Ridge Meadows Hospital is a 302-bed community hospital. The outpatient oncology unit was created in 1997 with a focus on adult patients with solid tumours and malignant hematologic conditions. On average, 15 patients are booked to undergo chemotherapy in this outpatient unit each week. The oncology team, consisting of an oncologist, a nurse, a dietitian, [...]
INTRODUCTION During the past 40 years, the roles of the pharmacy technician have expanded to services beyond traditional duties within the pharmacy department, correlating with the ever-changing needs of the health care system. In other countries, such as the United Kingdom, the roles of pharmacy technicians go beyond those of their Canadian counterparts to include [...]
For many medications, the effect on drug dosing regimens of clearance due to continuous renal replacement therapy is unknown. The risk of toxic effects because of drug accumulation due to overestimation of clearance and the risk of therapeutic failure due to underestimation of extracorporeal drug clearance are major concerns for critically ill patients undergoing such therapy. [...]
Twenty-five studies were identified that included data on the pharmacokinetics of medications for patients undergoing CVVHDF with AN69 filter membranes and a Gambro, Hospal, or Prisma dialyzer. One study on cefepime was excluded because the data indicated that CVVHDF clearance was greater than total body clearance for the study population, an impossible result. The methods [...]
The MEDLINE (1950 to January week 1, 2008) and EMBASE (1980 to 2008 week 1) databases were searched to identify articles reporting studies of the pharmacokinetics and disposition of drugs in patients undergoing continuous renal replacement therapy. The following terms were used for the MEDLINE search: “AN69″, “hemofiltration”, “hemodialfiltra- tion”, “continuous venovenous hemodialysis”, “renal replacement [...]
INTRODUCTION Continuous renal replacement therapy is increasingly used as an effective method of extracorporeal blood purification in critically ill patients. The indications for renal replacement therapy include acute or chronic kidney disease, refractory metabolic acidosis, multiple organ system failure, or refractory volume overload. Continuous renal replacement therapy may be continued for several days after initiation [...]
