To the authors’ knowledge, this study represents the largest case series on the use of IV ethanol therapy for the management of methanol or ethylene glycol poisoning. Despite difficulty in achieving target serum ethanol concentrations, treatment with IV ethanol therapy and hemodialysis was associated with favourable patient outcomes. Of the 27 patients, 25 (93%) survived, [...]
Adverse Effects Because this was a retrospective study that depended on information available in the medical record, the incidence of hypoglycemia was the only adverse effect evaluated. Of the 162 serum glucose determinations during the IV ethanol infusions, none had a value below 4 mmol/L.
Of 32 cases of potential methanol or ethylene glycol poisoning that were identified, 5 patients were excluded for the following reasons: 2 patients with confirmed ingestion had received ethanol infusions of less than 6 h duration; for 2 patients there was insufficient documentation of the initiation and discontinuation times of the ethanol infusion, which made [...]
Experimental Design For this retrospective study, patients admitted to The Ottawa Hospital—General Campus, an adult tertiary-care hospital, for methanol or ethylene glycol poisoning between January 1995 and February 2002 were identified by screening the hospital’s medical records for specified codes from the International Classification of Diseases, 9th revision, and their medical records were reviewed. The [...]
INTRODUCTION Poisoning with methanol or ethylene glycol is potentially life-threatening, and prompt treatment is required to reduce the risk of permanent sequelae, such as renal dysfunction, visual disturbances, or death. The toxic effects of methanol and ethylene glycol result from their conversion to toxic metabolites: methanol is converted to formic acid, whereas ethylene glycol undergoes [...]
Esophageal intraluminal impedance recording can be useful for characterizing the components of GERD and for discerning weak or nonacidic GERD, which would be missed by standard esophageal pH monitoring. The current study quantified the diagnostic gain contributed by pH-impedance recording in 220 patients who were undergoing evaluations for typical GERD symptoms (133 patients), respiratory symptoms [...]
